Influences of hypercholesterolemia on the vessel function of isolated rat thoracic aorta.
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The Effect of Flavonoid Naringenin on Contractile Response of Thoracic Aorta Isolated from Diabetic Rats
Background & Aims: Considering increasing incidence of cardiovascular disorders in diabetes mellitus and some evidence on antioxidant and antidiabetic potentials of naringenin, this study was conducted to evaluate the beneficial effects of 6-week administration of naringenin on contractile reactivity of isolated thoracic aorta in diabetic rats. Methods: Male Wistar rats were divided into contro...
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Background: The achievement of an effective compound for prevention/treatment of hypertension with fewer complications has been of interest in recent years. OBJECTIVES: This study aimed to examine the effects of L-citrulline pretreatment on the tension of isolated rat aortic tissues precontracted by different vasoconstrictors. METHODS: Sixteen male Wistar rats (300-350g) were randomly divided i...
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Heartworm extract induces relaxation of isolated rat thoracic aorta
Isolated rat thoracic aortic strips undergoing noradrenaline-induced contraction were treated with an adult heartworm (HW) crude extract and then examined for isometric changes in tension. HW extract caused relaxation of endothelium-intact strips, but not endothelium-denuded strips. This effect was inhibited by treatment with NG-nitro-L-arginine methyl ester hydrochloride (L-NAME) and could be ...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1992
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.99.181